Herpetiform pemphigus without anti-desmoglein 1/3 autoantibodies
نویسندگان
چکیده
منابع مشابه
Desmoglein 1 and desmoglein 3 are the target autoantigens in herpetiform pemphigus.
OBJECTIVE To determine the cell surface autoimmune target of herpetiform pemphigus (HP). DESIGN Serum samples of HP were examined by immunoblot studies with human epidermal extracts, enzyme-linked immunosorbent assay with baculovirus-expressed recombinant desmoglein (rDsg) 1 and rDsg3, and immunoadsorption assay with rDsg. PATIENTS Twenty serum samples were obtained from patients with HP wh...
متن کاملPathogenic activity of circulating anti-desmoglein-3 autoantibodies isolated from pemphigus vulgaris patients
INTRODUCTION There are scarce data on immunochemical properties of pemphigus antibodies detected in clinical remission in pemphigus vulgaris (PV) patients. The aim of the study was to compare biological activity of anti-Dsg3 autoantibodies purified from the sera of PV patients in active stage and in clinical remission. MATERIAL AND METHODS The effect of purified antibodies on expression of pr...
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415 5. Varga EA, Kerlin BA, Wurster MW. Social and ethical controversies in thrombophilia testing and update on genetic risk factors for venous thromboembolism. The effect of aspirin on haemostatic activity in the treatment of chronic venous leg ulceration. Pemphigus foliaceous (PF) is generally a benign autoim-mune blistering disease, but in some patients lesions are severe with serious implic...
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Autoantibodies against the epidermal desmosomal cadherins desmoglein 1 (Dsg1) and Dsg3 have been shown to cause severe to lethal skin blistering clinically defined as pemphigus foliaceus (PF) and pemphigus vulgaris (PV). It is unknown whether antibody-induced dissociation of keratinocytes is caused by direct inhibition of Dsg1 transinteraction or by secondary cellular responses. Here we show in...
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8. Ishii K, Amagai M, Komai A, Ebihara T, Chorzelski TP, Jablonska S, et al. Desmoglein 1 and desmoglein 3 are the target autoantigens in herpetiform pemphigus. Arch Dermatol. 1999;135:943--7. 9. Nakashima H, Fujimoto M, Watanabe R, Ishiura N, Yamamoto AI, Hashimoto T, et al. Herpetiform pemphigus without antidesmoglein 1/3 autoantibodies. J Dermatol. 2010;37:264--8. 10. O’ Toole EA, Mak LL, Gu...
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ژورنال
عنوان ژورنال: The Journal of Dermatology
سال: 2010
ISSN: 0385-2407,1346-8138
DOI: 10.1111/j.1346-8138.2009.00786.x